Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis
نویسندگان
چکیده
منابع مشابه
Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis
Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease. Thrombin, by acting on protease activated receptors (PAR), is one of the most potent platelet activators. PAR-1 antagonists may therefore provide more comprehensive antithrombotic effects. We review the pathophysiology of...
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OBJECTIVE The glycoprotein (GP) Ib-V-IX complex regulates the adhesion, activation, and procoagulant activity of platelets. We previously reported that RAM.1, a rat monoclonal antibody directed against the extracellular domain of mouse GPIbβ, diminished adhesion of platelets and chinese hamster ovary cells transfected with the human GPIb-IX complex to von Willebrand factor under flow conditions...
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T he finding that humans with hereditary factor XI deficiency have relatively mild bleeding tendencies—yet are significantly protected against certain thrombotic diseases— has sparked considerable interest in factor XI/XIa as a target for novel antithrombotic treatments. In the classic waterfall description of blood coagulation, there are 2 ways to trigger the plasma clotting system: the tissue...
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RATIONALE Glutamate is a major signaling molecule that binds to glutamate receptors including the ionotropic glutamate receptors; kainate (KA) receptor (KAR), the N-methyl-d-aspartate receptor, and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Each is well characterized in the central nervous system, but glutamate has important signaling roles in peripheral tissues as w...
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Clinical manifestations of atherothrombotic disease, such as acute coronary syndromes, cerebrovascular events, and peripheral arterial disease, are major causes of mortality and morbidity worldwide. Platelet activation and aggregation are ultimately responsible for the progression and clinical presentations of atherothrombotic disease. The current standard of care, dual oral antiplatelet therap...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2013
ISSN: 1424-8247
DOI: 10.3390/ph6080915